Long-term changes in glutamatergic synaptic transmission in phenylketonuria
نویسندگان
چکیده
منابع مشابه
Long-term changes in glutamatergic synaptic transmission in phenylketonuria.
The cellular mechanisms that underlie impaired brain function during phenylketonuria (PKU), the most common biochemical cause of mental retardation in humans, remain unclear. Acute application of L-Phe at concentrations observed in the PKU brain depresses glutamatergic synaptic transmission but does not affect GABA receptor activity in cultured neurons. If these depressant effects of L-Phe take...
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ژورنال
عنوان ژورنال: Brain
سال: 2004
ISSN: 1460-2156
DOI: 10.1093/brain/awh354